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Symbol
Name
ID 		Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
MGI:1100842
Phenotype annotations related to renal/urinary system
Darker colors indicate more annotations
Human Phenotypes
Proteinuria
Moderate proteinuria
Vesicovaginal fistula
Functional abnormality of the bladder
Urinary incontinence
Vesicoureteral reflux
Congenital posterior urethral valve
Abnormal nephron morphology
Thickened glomerular basement membrane
Abnormal renal tubule morphology
Abnormal renal calyx morphology
Hydronephrosis
Enlarged kidney
Multicystic kidney dysplasia
Renal dysplasia
Renal hypoplasia/aplasia
Bilateral renal agenesis
Pyelonephritis
Renal insufficiency
Chronic kidney disease
Hydroureter
Ureteral agenesis
Ureteral atresia
Ureterocele
Recurrent urinary tract infections
Disease(s) Associated with GFRA1
renal agenesis

Mouse Phenotypes
abnormal kidney morphology
abnormal kidney development
small kidney
absent nephron
absent kidney
single kidney
abnormal ureter morphology
absent ureter
large ureter
abnormal urinary bladder morphology
abnormal ureteric bud morphology
abnormal branching involved in ureteric bud morphogenesis
impaired branching involved in ureteric bud morphogenesis
abnormal ureteric bud invasion
abnormal ureteric bud tip morphology
absent ureteric bud
Availability Mouse Genotype
Gfra1tm1(cre/ERT2)Sjn/Gfra1tm1(cre/ERT2)Sjn
Gfra1tm1Bjh/Gfra1tm1Bjh
Gfra1tm1Jmi/Gfra1tm1Jmi
Gfra1tm1Rosl/Gfra1tm1Rosl
Gfra1tm2.1Jmi/Gfra1tm2.1Jmi
Gfra1tm3Jmi/Gfra1tm3Jmi
Gfra1tm2Jmi/Gfra1tm1(cre/ERT2)Sjn  (conditional)
Gfra1tm2Jmi/Gfra1tm3Jmi
Tg(Hoxb7-cre)13Amc/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory